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Malaria vaccine becomes first to achieve 75% efficacy goal in trial of children

BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n1078 (Published 23 April 2021) Cite this as: BMJ 2021;373:n1078
  1. Elisabeth Mahase
  1. The BMJ

A vaccine candidate for malaria has become the first to meet the World Health Organization’s 75% efficacy target, after a trial in 450 children reported 77% efficacy.1

The phase II trial included infants aged five to 17 months from 24 villages in Nanoro, Burkina Faso. Participants were split into three groups—low dose, high dose, and a rabies vaccine control group—with doses administered from May to August 2019.

The results, released through Preprints with The Lancet, showed that the higher dose version of the vaccine had 77% efficacy and the lower dose had 71% efficacy over a 12 month follow-up period. No serious adverse events related to …

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