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Covid-19: People who have had infection might only need one dose of mRNA vaccine

BMJ 2021; 372 doi: (Published 02 February 2021) Cite this as: BMJ 2021;372:n308

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  1. Jacqui Wise
  1. London

People who have already had confirmed covid-19 might only need a single dose of a mRNA vaccine, two small studies have indicated.

The first study, which was published as a preprint and has not yet been peer reviewed, found that seropositive individuals had a rapid antibody response after one dose of either the Pfizer-BioNTech or Moderna vaccines.1 It also found that people who had previously had covid-19 reported side effects more frequently after the first dose—in line with the level reported for the second dose in phase III vaccine trials.

The researchers, from Mount Sinai in New York and Paris, examined the antibody responses in 109 people—68 of them had never had covid-19, whereas 41 had …

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