COVID-19 variants, epitope change, vaccine escape, booster doses of new COVID-19 vaccine
The report that "Moderna plans booster doses to counter variants" is very interesting . The main question is whether giving booster doses can overcome the problem of new COVID-19 variants such as African variant. Regarding the COVID-19 variant, the molecular change occurs and it might further alter epitope properties. There might be a vaccine escape phenomenon and if vaccine escape occurs, the first generation vaccine might not be effective. Therefore, vaccine boostering might not be the way to correspond to the new COVID-19 variants.
1. Covid-19: Moderna plans booster doses to counter variants. BMJ 2021; 372 doi: https://doi.org/10.1136/bmj.n232
Competing interests: No competing interests