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Covid-19: Reports from Israel suggest one dose of Pfizer vaccine could be less effective than expected

BMJ 2021; 372 doi: https://doi.org/10.1136/bmj.n217 (Published 22 January 2021) Cite this as: BMJ 2021;372:n217

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  1. Elisabeth Mahase
  1. The BMJ

Concerns have been raised over how much protection a single dose of the Pfizer BioNTech covid-19 vaccine provides, following reports from Israel that it is much lower than expected.

Israel, which, like the UK, is currently in its third national lockdown, has so far vaccinated more than 75% of its older people with at least one dose. Early reports from the vaccine rollout have suggested that the first dose led to a 33% reduction in cases of coronavirus1 compared with efficacy of at least 52% reported in clinical trials.2

A preliminary report from the Clalit Research Institute compared the infection data of 200 000 people aged 60 and over who were not vaccinated with the infection …

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