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Aortic stenosis, cardiac death risk . . . and other stories

BMJ 2020; 371 doi: https://doi.org/10.1136/bmj.m4081 (Published 29 October 2020) Cite this as: BMJ 2020;371:m4081

Sudden cardiac death

Decisions about the timing of surgery for people with asymptomatic aortic stenosis must balance the risks of intervention against the possible harms of watchful waiting. Among the latter is the possibility of sudden cardiac death which, according to a recent longitudinal study, is small but not negligible. Among 1849 asymptomatic people, 27 sudden cardiac deaths occurred over four years of follow-up (Heart doi:10.1136/heartjnl-2019-316493). The strongest predictors were age and left ventricular hypertrophy.

Methotrexate and malignant melanoma

People with psoriasis whose condition does not respond to topical treatment and phototherapy are often given methotrexate. Although frequently effective, the drug has …

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