Should countries aim for elimination in the covid-19 pandemic?
BMJ 2020; 370 doi: https://doi.org/10.1136/bmj.m3410 (Published 09 September 2020) Cite this as: BMJ 2020;370:m3410Read our latest coverage of the coronavirus outbreak
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Dear Editor
Many of the arguments raised by Thornley et al in the BMJ’s recent head-to-head debate (BMJ 2020;370:m3410) against taking an elimination approach to COVID-19 are in our view misleading and incorrect. In particular, their mistaken assertion that the infection fatality risk (IFR) for COVID-19 is “similar to that for seasonal flu”.
Research conducted in New Zealand (NZ) and internationally suggests that the IFR for COVID-19 is typically at least an order of magnitude higher than for seasonal flu. The most detailed study of seasonal influenza mortality in NZ to date estimated average annual mortality of 13.5 (95%CI 13.4, 13.6) per 100,000 population [1]. Furthermore, the proportion of the NZ population infected with influenza in a year has been measured from a seroconversion study at 35% (95%CI: 32%-38%) [2]. Combining these figures suggests an IFR for seasonal influenza of about 0.039% (ie, 13.5/35,000) in NZ. This seasonal influenza IFR is 17 times lower than that estimated for COVID-19 at 0.68% [3] and 0.65% [4], based on international data (there have been too few COVID-19 cases in NZ to produce an IFR estimate).
Furthermore, as Lee points out in the same debate article, there is growing evidence for long-term health impacts from COVID-19 which need to be considered when comparing the elimination strategy with the alternative suppression or mitigation approaches [5].
It is reasonable to debate the COVID-19 elimination strategy as it is likely that the feasibility of achieving this goal will vary by country circumstances. That is, it seems hard for countries with large land borders, federal systems, and dysfunctional governments; but more feasible for island nations such as New Zealand (NZ) [6]. But such debates need to use correct data.
References
1. Khieu TQT, Pierse N, Telfar-Barnard LF, et al. Modelled seasonal influenza mortality shows marked differences in risk by age, sex, ethnicity and socioeconomic position in New Zealand. J Infect 2017;75(3):225-33. doi: 10.1016/j.jinf.2017.05.017 [published Online First: 2017/06/06]
2. Huang QS, Bandaranayake D, Wood T, et al. Risk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study. J Infect Dis 2019;219(3):347-57. doi: 10.1093/infdis/jiy443 [published Online First: 2018/07/18]
3. Meyerowitz-Katz G, Merone L. A systematic review and meta-analysis of published research data on COVID-19 infection-fatality rates. medRxiv 2020;(7 July). doi: https://doi.org/10.1101/2020.05.03.20089854.
4. Centers for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19): Pandemic planning scenarios. 2020;(10 July). https://www.cdc.gov/coronavirus/2019-ncov/hcp/planning-scenarios.html.
5. Mahase E. Covid-19: What do we know about "long covid"? BMJ 2020;370:m2815. doi: 10.1136/bmj.m2815 [published Online First: 2020/07/16]
6. Baker MG, Wilson N, Anglemyer A. Successful elimination of Covid-19 transmission in New Zealand. N Engl J Med 2020;(7 August) doi:101056/NEJMc2025203 https://wwwnejmorg/doi/101056/NEJMc2025203?url_ver=Z3988-2003&rfr_id=ori... 2020 doi: 10.1056/NEJMc2025203 [published Online First: 2020/08/09]
Competing interests: No competing interests
Dear Editor,
The debate about control and possible elimination of covid-19 has focused on costs and harms versus benefits, and has tended to overlook important ethical questions of who benefits and who pays. The benefits of control measures will mainly apply to the middle-aged and elderly, but the cost, in terms of long term economic disruption, unemployment, damaged educational prospects, and psychological illness, will hit the younger generation hardest.
Public health policy decisions tend to be made by middle-aged and elderly policitican, doctors and academics; the young are not given a say, and are shamed or even criminalised if they do not comply. We would not compel a young person to donate a kidney to an elderly relative, or to have any medical procedure that was not in their own best interests, but public health interventions seem to be in a different moral category: we are happy to force our young sacrifice their economic, social and psychological freedoms so that the older generation can live a bit longer.
Competing interests: No competing interests
Dear Editor
Once again we see an analysis that focuses upon the coronavirus and not the host. Both SAGE and iSAGE appear to live in a world devoid of knowledge of the profound effects of the secosteroid hormone D3 upon our immune defences, both innate and adaptive. To cut to the quick (because I am getting bored repeating the message), the latest clinical trial in Cordoba showed a dramatic 25-FOLD reduction in severity of COVID-19 following oral administration of a bolus of 25(OH)D3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/
This dramatic result was not unexpected by those of us who are familiar with Schwalfenberg's "D3 hammer": https://www.cfp.ca/content/61/6/507.long . The doses used are similar. There already exists an extensive research base implicating D3-deficiency in COVID-19: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3669379
By physiological criterion of serum 25(OH)D =100 to 150 nmol/L (the level achieved as a matter of routine by Schwalfenberg's patients) a very high percentage of the human population are deficient. A highly cogent argument can be made that the virus is exploiting this gap in our defences. That gap that can be rapidly closed, both cheaply and safely. Cost: a few pence per day per person.
Competing interests: No competing interests
Dear Editor,
When considering whether countries should aim for elimination in the COVID-19 pandemic, there are essentially two questions to answer.
1. Is elimination possible at all?
2. Do the benefits of achieving elimination outweigh the costs of pursuing it?
If the answer to either question is negative then it is obvious that elimination would not be a valid approach. On the first question there is much doubt, but for the purposes of discussion let us assume that it is possible to achieve elimination.
The focus then becomes on how to achieve elimination, and whether the measures required would cause more suffering than would be saved by achieving the goal. A simple cost/benefit analysis in theory, but remarkably difficult to do in practice because there is so much disagreement over the negative effects of the virus and the negative effects of the measures required. With so little consensus it becomes important to focus on the features of the virus that are most widely accepted, so that our starting point can at least be agreed.
ESSENTIAL CHARACTERISTICS OF THE VIRUS
From the early days of this virus two things quickly became apparent. Firstly that it is capable of very rapid spread amongst people showing no symptoms, and secondly that certain groups of the population appear far more likely to suffer from it than others. These are the essential characteristics of this virus.
Although the extent of asymptomatic spread is still debated and although 'Long COVID' has emerged as an issue, it seems that the essential characteristics are still largely accepted. It is these essential characteristics that must dictate our response to the virus.
The first characteristic (rapid 'invisible' spread) makes it extremely difficult to put in place targeted measures. Restrictions which target people showing symptoms do not suffice, so the steps that have been taken start from the point that everyone is a potential carrier/spreader. The healthy majority are treated identically to the sick minority in order to prevent the sickness spreading. This in turn leads many to perceive the reaction as disproportionate in respect of the restriction of liberty that is involved. The economic, social and corresponding health costs are hard to calculate, but it is generally accepted now that lockdown and other restrictive measures exert a heavy toll on almost all groups in society, with certain more vulnerable groups worst affected.
All of this means that in order to achieve elimination we must battle the virus in the area that it is hardest to defeat - ease of spread - and we must employ measures that we are hugely uncomfortable with, and which may end up costing more than is gained by victory. Given the problems with elimination we need to at least consider the alternatives.
ALTERNATIVES TO ELIMINATION
The other essential characteristic of the virus gives us a clue as to an alternative strategy. This is the idea of specifically protecting the most vulnerable while the less vulnerable are left to carry on, taking the chance of infection.
Although there is logic to freeing up the majority of society to act as previously while protection efforts are concentrated on those most in need, there have been very few practical suggestions as to how this could feasibly be achieved. Isolation of the vulnerable seems to create or exacerbate the same problems as lockdown for those affected, and would force families to split in a way that the current household bubble approach does not. The question of who is vulnerable is also a difficult one to answer. We know that broadly risk increases with age and co-morbitities, but drawing arbitrary lines at a certain age or for people with certain conditions fails to recognise that there are huge disparities between individuals within the same age range. It would be hard to justify that a - say - 64 year old one day should be free to act as they choose, but isolated on the day they turn 65. And is that something society would want to enforce upon people?
If the route to elimination and isolation of the vulnerable both cause too much suffering then what next? Practical suggestions have been largely absent amongst the torrent of voices who question the lockdown approach. But some do exist. One such example is the targeted protection advocated by the greenbandredband system. This approach proposes that all adults be given the right to choose whether to class themselves as vulnerable or low risk. No arbitrary lines, just a personal choice based on personal risk assessment. From there very simple rules exist. For those who classify themselves as vulnerable, distancing/protection measures similar to those in place currently would be maintained. The low risk would also follow these rules when interacting with the vulnerable. But where low risk individuals mixed with each other, they would not be bound by distancing rules.
This very simple system offers multiple benefits compared to the status quo, the isolation of the vulnerable or compared to an unmitigated spread of the virus.
Firstly it removes most of the concerns around the erosion of traditional freedoms or human rights. The system is based on choice, and this choice is a free one offered to all individuals. With choice comes flexibility and the ability to recognise that each situation is nuanced. For instance if a person who would otherwise be low risk happens to be in regular close contact with (e.g. lives with) a vulnerable individual then they might choose to classify themselves as vulnerable in order not to put their housemate at greater risk.
Secondly it protects the vulnerable. On the basis of the first essential virus characteristic, spread of the virus amongst the lower risk (self identified) would almost certainly increase compared to the current situation, but on the basis of the second essential characteristic, this would not result in a significant increase in hospitalisations or suffering. The current concern that increased cases amongst the young will inevitably lead to increased cases amongst the old would be addressed by the system's basic principle that the low risk must respect protection measures in their interaction with the vulnerable.
Thirdly it offers the prospect of increased freedom for the low risk to return to something closer to a pre-virus existence. Economic recovery will be assisted by more people being able to return to work and businesses being able to increase their capacity for those who are content to take the risk of infection.
Finally it buys us time by making it easier for people to 'follow the rules'. The world is waiting for an effective vaccine, but the wait is a painful one. The longer people are asked to make sacrifices - particularly people who are in the less vulnerable groups - the less accepting they become and the more splintered society becomes. The greenbandredband system still requires all individuals to moderate their behaviour, but the restrictions are far less intrusive and far easier to understand than the current mishmash of constantly changing and inconsistent rules and guidance. By making the rules easier to stick to and easier to understand they are far more likely to gain general and long term acceptance.
By instituting a system such as greenbandredband, the government could move into an advisory role. Rather than prohibit or allow, the government could focus on informing people so that they were best equipped to make sensible and considered assessments of their risk. These might well change as circumstances and scientific knowledge evolve, but the system allows for people to change their mind and reclassify themselves into the other category.
Whereas all other proposals for a response to the virus require considerable amounts of money to be spent, the greenbandredband system requires virtually no investment and could be put in place extremely quickly. All that is required is for people to understand the rules and to clearly communicate their position with others.
All details of how the system would work can be found on the website https://greenbandredband.com.
Competing interests: No competing interests
Dear Editor
Thornley and colleagues confuse eradication, permanent reduction to zero of the worldwide incidence of infection, the reduction to zero of infection in a defined geographical area.(1) New Zealand, and other countries, have demonstrated that elimination of SARS-CoV-2 transmission can be achieved for periods of time, even though the virus may, from time to time, be imported either in infected individuals or on fomites, as seems likely to have been the case in Auckland. An elimination strategy accepts this and adopts measures to prevent further spread throughout the country. New Zealand has been successful in doing this with the recent outbreak.
As Thornley and colleagues note, it is difficult to be certain what the case fatality rate is, but the range they quote is below the now generally accepted figure of 0.5% to 1%.(2) This is considerably higher than for seasonal flu. However, as we now know, a narrow focus on deaths ignores what is emerging as a major problem, so-called Long COVID. (3) A failure to bear down on this disease risks leaving very large numbers of people with long term disability. Moreover the claim that SARS-CoV-2 “is not dramatically life shortening” seems strange given evidence that each COVID death causes, on average, 12-14 years of life lost.(4)
Their pessimism about vaccines is remarkable. There is no previous case in which the genome of a new virus was decoded within days or a vaccine progressed to phase 3 trials within months. Especially in light of the encouraging evidence so far, their suggestion that this could take 10 years is difficult to understand.
As is now clear from many countries, as long as this virus continues to circulate in significant quantities, any lifting of restrictions will allow infections to spread unless there is a robust system to find, test, trace, isolate and support. The historical evidence from 1918 is clear.(5) Those places that imposed the strictest limitations and retained them longest saw a faster economic recovery. Moreover, as is all too clear, there is little point in removing restrictions if a large proportion of the population are too worried to place themselves at a real or perceived risk.
No-one pretends that achieving Zero COVID is easy, but in the long term the alternative is far worse.
1. Dowdle WR. The principles of disease elimination and eradication. Bull World Health Organ 1998;76 Suppl 2:23-5.
2. Mallapaty S. How deadly is the coronavirus? Scientists are close to an answer. Nature. 2020 Jun 1;582(7813):467-8.
3. Greenhalgh T, Knight M, A’Court C, Buxton M, Husain L. Management of post-acute covid-19 in primary care. BMJ 2020; 370
4. Hanlon P, Chadwick F, Shah A et al. COVID-19 – exploring the implications of long-term condition type and extent of multimorbidity on years of life lost: a modelling study [version 1; peer review: 1 approved]. Wellcome Open Res 2020, 5:75 (https://doi.org/10.12688/wellcomeopenres.15849.1)
5. McKee M, Stuckler D. If the world fails to protect the economy, COVID will damage health not just now but also in the future. Nature Med 2020; 26: 640–642
Competing interests: I am a member of Independent SAGE, which argues for a Zero COVID strategy
Dear Editor,
Eliminating CoVID-19:
It is matter of what one desires and what one can achieve.
It is also a question, "At What Cost?" Is a Pyrrhic Victory desirable?
It is a question of allocating resources wisely to various aspects of public needs.
As far as the feasibility goes: we desire eradication of many maladies: Tuberculosis, Malaria, Chikungunya, Dengue, Leprosy, Substance Abuse, HIV, Hepatitis C, Hepatitis B, Ebola, Zika Virus, Nipah Virus. In fact, a whole Gamut of Infections --leaving aside a very few exceptions like Smallpox -- and an entire group of Lifestyle related Aging related, Genetic, and Pollution and Climate Change related problems, as well as Poverty and its fallout.
No! There is no end to most of the maladies that individuals, families, Society and Humanity in general suffer.
One can always adopt a Pragmatic view. Actions come first, outcomes become apparent later. Wisdom and foresight to make right choices is endowed to only a few!
Hope, an optimal path is chosen!
Arvind Joshi, MBBS MD FCGP FAMS FICP.
Competing interests: No competing interests
Re: Should countries aim for elimination in the covid-19 pandemic?
Dear Editor
I would wish to endorse Martin McKee’s view that there is undue pessimism regarding vaccination here. Not only has encouraging vaccine development been remarkably fast, but its effect at a population level needs to be considered.
An effective vaccine clearly gives good individual protection, but even a less effective vaccine may have a strong effect on a population. Males are vaccinated against rubella, but this has clearly no direct individual effect on rubella associated developmental abnormalities. However, the reduction in the population prevalence of rubella that is augmented by vaccination of males as well as females will reduce the risk for the offspring of even unvaccinated females.
When vaccines are introduced in a population, it will be important to study the effect on the population as a whole, not just on vaccinated individuals as in the phase 3 trials. These population effects can probably only be studied by observational studies, but nonetheless they will be valuable in understanding the effect on the reproduction number (R - the average number of secondary infections in a population produced by a single infected person).
When these results are available we will know better the answer to the Head to Head question posed here.
Competing interests: No competing interests