Intended for healthcare professionals


Predicting multiple sclerosis progression . . . and other stories

BMJ 2020; 369 doi: (Published 25 June 2020) Cite this as: BMJ 2020;369:m2437

Aggressive multiple sclerosis

A small proportion of people who develop multiple sclerosis experience a rapid progression of their disease and become severely disabled within a few years. A bayesian analysis of an international database attempted to identify predictors of this aggressive form of multiple sclerosis (Brain doi:10.1093/brain/awaa081). The three strongest predictive factors were age 35 or older at symptom onset, rapid progression of disability in the first year, and the presence of pyramidal signs. The findings were validated in a second group of patients from the Swedish Multiple Sclerosis Registry.


People with trichotillomania pull out hair from their scalp, eyebrows, and other areas of their body. For some, the condition is mild and manageable—no worse than the need some people feel to bite their nails. In others, the urge to pull out hair is overwhelming, leaving bald spots, and interfering with social and work activities. A systematic …

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