Re: Preventing a covid-19 pandemic: are steroids a risk factor?
ACE2 Receptor Expression and SARS Coronavirus Infection depends on differentiation of human airway epithelia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1287568/
‘Airway epithelial expression of ACE2 is dynamic and associated with cellular differentiation, a finding that may underlie susceptibility to infection.'
Might compounds for example glucocorticoids that affect differentiation of these cells be worth evaluating as a risk factor for Covid-19?
The ACE2 protein is also distributed in other tissues.
Including ‘High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa’ https://www.nature.com/articles/s41368-020-0074-x
Competing interests: No competing interests