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Preventing a covid-19 pandemic

BMJ 2020; 368 doi: https://doi.org/10.1136/bmj.m810 (Published 28 February 2020) Cite this as: BMJ 2020;368:m810

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Re: Preventing a covid-19 pandemic

Dear Editor

Might I suggest that a simple, safe and cheap solution to protecting those in self-isolation, especially the elderly, lies in this "D3 hammer". The therapy was introduced in a GP environment in Canada over 5 years ago:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463890/

There is an extensive body of science underpinning the approach. "Vitamin" D3 is in reality a hormone and autocrine signal that acts as a superpromoter for ca 2000 genes, 10% of our genome, with a broad defensive function. D3 is known to up-regulate expression of the anti-microbial peptides cathelicidin and defensins that act against bacteria, fungi and enveloped viruses. Corona viruses are of course enveloped. The VDRE is present in human lung epithelial cells. To me the dots are joined up and the picture points to an unexploited potential emergency therapy for covid-19, especially in the elderly who are typically severely D3 defiicient by physiological criteria, and at highest risk.

Competing interests: No competing interests

02 March 2020
Peter H Cobbold
Emeritus Professor, Cell Biology
University of Liverpool, UK
North Wales