Intended for healthcare professionals

  1. Education
  2. Tranexamic acid is...
  3. Tranexamic acid is safe to use following mild-to-moderate traumatic brain injury
Practice NIHR Signals

Tranexamic acid is safe to use following mild-to-moderate traumatic brain injury

BMJ 2020; 368 doi: https://doi.org/10.1136/bmj.m514 (Published 11 March 2020) Cite this as: BMJ 2020;368:m514

Editorial

NIHR’s research signals in The BMJ
  1. Rob Cook, clinical director1,
  2. Johnny Lyon-Maris, clinical adviser2,
  3. Rosie Martin, clinical specialist1
  4. on behalf of NIHR Dissemination Centre
  1. 1Bazian, Economist Intelligence Unit healthcare, London, UK
  2. 2Wessex Institute, University of Southampton, Southampton, UK
  1. Correspondence to R Cook rob.cook{at}bazian.com

The study

The CRASH-3 Trial Collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial.Lancet 2019;394:1713-23.

This trial was funded by NIHR Health Technology Assessment Programme (project number 14/190/01), JP Moulton Charitable Trust, Department of Health and Social Care, Department for International Development, Global Challenges Research Fund, Medical Research Council, and the Wellcome Trust (Joint Global Health Trials scheme).

To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000870/tranexamic-acid-following-mild-to-moderate-traumatic-brain-injury-is-safe-and-reduces-deaths

Footnotes

  • Competing interestsThe BMJ has judged that there are no disqualifying financial ties to commercial companies. The authors declare the following other interests: none.

  • Further details of The BMJ policy on financial interests is here: https://www.bmj.com/about-bmj/resources-authors/forms-policies-and-checklists/declaration-competing-interests

  • All authors contributed to development and review of this summary, as part of the wider NIHR Signals editorial team (https://www.bmj.com/NIHR-signals). RC is guarantor.

  • Contributor Gaby Richter

  • Disclaimer NIHR Signals are owned by the Department of Health and Social Care and are made available to The BMJ under licence. NIHR Signals report and comment on health and social care research but do not offer any endorsement of the research. The NIHR assumes no responsibility or liability arising from any error or omission or from the use of any information contained in NIHR Signals.

  • Permission to reuse these articles should be directed to disseminationcentre@nihr.ac.uk.

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