Re: Use of AT1 receptors antagonists in corona virus disease
I think that the idea of the possible usefulness of angiotensin II receptor blockers (like Irbesartan, losartan, etc.) in the treatment of COV-19 virus disease may derive from a paper publshed in 2005 (NATURE MEDICINE VOLUME 11 | NUMBER 8 | AUGUST 2005).
In that paper it was demonstrated that SARS-CoV, binding on ACE2 enzyme, induces the formation of an excess of ATII, thus leading to severe lung injury.
The use of "sartans" can't be presumed as antiviral therapy, nonetheless it could ameliorate the pulmonary deleterious effects of the virus infection.
Competing interests: No competing interests