Do PCSK9 inhibitors do anything more than reduce LDL cholesterol?BMJ 2020; 368 doi: https://doi.org/10.1136/bmj.m1159 (Published 24 March 2020) Cite this as: BMJ 2020;368:m1159
- Andrew N Bamji, retired consultant rheumatologist
- Rye TN31 7ES, UK
Byrne and colleagues point out the lack of reliable evidence on cardiovascular risk with inclisiran, and the omens are not good.1
Inclisiran undoubtedly has a marked lowering effect on low density lipoprotein (LDL) cholesterol, which was first reported in 2017. But does a 30-50% reduction in LDL cholesterol translate to a 30-50% reduction in cardiovascular risk? Almost certainly not.
The inclisiran results include an “exploratory cardiovascular endpoint” (a secondary …