Intended for healthcare professionals


Nerve fibre function and fibromyalgia . . . and other stories

BMJ 2019; 367 doi: (Published 07 November 2019) Cite this as: BMJ 2019;367:l6279


Fibromyalgia is characterised by chronic widespread pain, fatigue, and sleep disturbance. Its causation is poorly understood, but in the past few years, small studies have hinted that impairment of peripheral unmyelinated nerve fibre function may be to blame. Detailed neurophysiological investigation of more than 100 people with fibromyalgia living in Germany confirmed widespread small nerve fibre dysfunction in the skin and cornea (Ann Neurol doi:10.1002/ana.25565). Severity of symptoms correlated with the extent of dermal denervation.

Optimism and longevity

Two longitudinal studies from the US report that people with an optimistic outlook have a lower mortality. Women in the Nurses Health …

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