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Routine use of progesterone does not prevent miscarriage

BMJ 2019; 367 doi: (Published 08 November 2019) Cite this as: BMJ 2019;367:l5721


NIHR’s research signals in The BMJ

  1. Rob Cook, clinical director1,
  2. Vaughan Thomas, clinical adviser2,
  3. Rachel Taft, clinical specialist1
  4. on behalf of the NIHR Dissemination Centre
  1. 1Bazian, Economist Intelligence Unit healthcare, London, UK
  2. 2Wessex Institute, University of Southampton, Southampton, UK
  1. Correspondence to R Cook rob.cook{at}

The study

Coomarasamy A, Devall AJ, Cheed V, et al. A randomised trial of progesterone in women with bleeding in early pregnancy N Engl J Med 2019;380:1815-24.

This project was funded by the NIHR Health Technology Assessment Programme (project number 12/167/26).

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  • Contributor: Yvonne Covell.

  • All authors contributed to development and review of this summary, as part of the wider NIHR Signals editorial team. RC is guarantor.

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  • Competing interests The BMJ has judged that there are no disqualifying financial ties to commercial companies. The authors declare the following other interests: none.

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