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Polypill cuts major cardiovascular events by a third, study finds

BMJ 2019; 366 doi: (Published 22 August 2019) Cite this as: BMJ 2019;366:l5268
  1. Stijntje Dijk,
  2. Pat Lok
  1. The BMJ

A once daily, low cost polypill combining four cardiovascular drugs reduced the risk of major cardiovascular events by a third over a five year period when compared with lifestyle advice, a large study has found.1

Poor adherence is particularly common among patients with cardiovascular disease, as previous studies suggest that around a third of patients stop taking their medicine as early as 90 days after a myocardial infarction.2

The concept of a polypill was first proposed over 15 years ago as a simple, cost saving approach to improve medicine adherence and reduce the burden of cardiovascular disease.3 But …

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