Intended for healthcare professionals

Letters Modernising vaccine surveillance systems

HPV vaccine: adverse event signals were minimised or ignored

BMJ 2019; 366 doi: (Published 05 July 2019) Cite this as: BMJ 2019;366:l4508
  1. Manuel Martínez-Lavín, chief
  1. Rheumatology Department, National Institute of Cardiology, Juan Badiano 1, 14080 Mexico City, Mexico
  1. drmartinezlavin{at}

Chandler discusses the difficulties in the pharmacovigilance of HPV vaccines due to the non-specific nature of dysautonomia symptoms reported to surveillance agencies.1

In our critical review, we found that serious adverse event signals were already present in the largest randomised trials of HPV vaccines. These signals were ignored or minimised.2 The group of 2881 women injected with the …

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