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Health outcomes of young children born to mothers who received 2009 pandemic H1N1 influenza vaccination during pregnancy: retrospective cohort study

BMJ 2019; 366 doi: https://doi.org/10.1136/bmj.l4151 (Published 10 July 2019) Cite this as: BMJ 2019;366:l4151

Linked editorial

Flu vaccination in pregnancy

Re: Influenza vaccines in pregnancy: the authors have extrapolated beyond their data

It is interesting that Peter Doshi and Tom Jefferson [1] note Zerbo et al's finding about autism [2], and the appropriateness of Zerbo's employment of a Bonferroni correction has been controversial [2-4] as Allan Cunningham [5] already pointed in a Rapid Response to the accompanying editorial by Håberg and Wilcox [6].

As someone who is appalled and bewildered by the apparent indifference of governments to the rise in autism (which is reaching budget breaking levels) [7] I would have thought we need to be pursuing every possible lead without fear or favour.

[1] Peter Doshi & Tom Jefferson, 'Influenza vaccines in pregnancy: the authors have extrapolated beyond their data', 2 August 2019, https://www.bmj.com/content/366/bmj.l4151/rr

[2] Brian S Hooker, 'Influenza Vaccination in the First Trimester of Pregnancy and Risk of Autism Spectrum Disorder', JAMA Pediatr. 2017;171(6):600. doi:10.1001/jamapediatrics.2017.0734

[3] Donzelli et al, 'Influenza Vaccination in the First Trimester of Pregnancy and Risk of Autism Spectrum Disorder', AMA Pediatr. 2017;171(6):601. doi:10.1001/jamapediatrics.2017.0753

[4] Zerbo et al, 'Influenza Vaccination in the First Trimester of Pregnancy and Risk of Autism Spectrum Disorder—Reply', JAMA Pediatr. 2017;171(6):601-602. doi:10.1001/jamapediatrics.2017.0737

[5] Allan S Cunningham, 'Re: Flu vaccination in pregnancy - FIRST TRIMESTER FLU SHOTS: NOT A GOOD IDEA', https://www.bmj.com/content/366/bmj.l4454/rr-0

[6] Håberg and Wilcox, 'Flu vaccination in pregnancy',
BMJ 2019; 366 doi: https://doi.org/10.1136/bmj.l4454 (Published 10 July 2019)

[7] John Stone, 'Re: Social care: pressure mounts for urgent and radical reform - the cost of Brexit is a blip compared with the cost of the unexplained surge in ASD', https://www.bmj.com/content/366/bmj.l4564/rr-1

Competing interests: No competing interests

04 August 2019
John Stone
UK Editor
AgeofAutism.com
London N22