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Copeptin and acute ischaemic stroke . . . and other stories

BMJ 2019; 365 doi: (Published 01 May 2019) Cite this as: BMJ 2019;365:l1830


Copeptin is released by the posterior pituitary at the same time as vasopressin. The usual stimulus for its secretion is osmotic but it is also released soon after physiologically stressful events. In acute myocardial infarction, for example, levels of copeptin rise before levels of troponin. A large case series from a hospital in Switzerland suggests it could also be a useful prognostic marker in acute ischaemic stroke (Neurology doi:10.1212/WNL.0000000000007177). The addition of copeptin levels to scores on the NIH Stroke Scale improved the accuracy of predictions of disability and death at three …

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