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Can treating vitamin D deficiency reduce exacerbations of chronic obstructive pulmonary disease?

BMJ 2019; 364 doi: (Published 18 March 2019) Cite this as: BMJ 2019;364:l1025


NIHR’s research signals in The BMJ

  1. Rob Cook, clinical director,
  2. Vaughan Thomas, clinical advisor,
  3. Rosie Martin, clinical specialist
  4. on behalf of NIHR Dissemination Centre
  1. 1Bazian, Economist Intelligence Unit healthcare, London, UK
  2. 2Wessex Institute, University of Southampton, Southampton, UK
  1. Correspondence to R Cook rob.cook{at}

The study

Jolliffe D, Greenberg L, Hooper R, Mathyssen C, Rafiq R, de Jongh R, Camargo C, Griffiths C, Janssens W, Martineau A. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax 2019. doi:10.1136/thoraxjnl-2018-212092.

This project was funded by the National Institute for Health Research Health Technology Appraisal programme (project number 13/03/25).

To read the full NIHR Signal, go to:


  • Competing interestsThe BMJ has judged that there are no disqualifying financial ties to commercial companies. The authors declare the following other interests: none.

  • Further details of the BMJ policy on financial interests is here:

  • Contributors Rebecca Goldman

  • All authors contributed to development and review of this summary, as part of the wider NIHR Signals editorial team ( RC is guarantor.

  • Disclaimer NIHR Signals are owned by the Department of Health and Social Care and are made available to the BMJ under licence. NIHR Signals report and comment on health and social care research but do not offer any endorsement of the research. The NIHR assumes no responsibility or liability arising from any error or omission or from the use of any information contained in NIHR Signals.

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