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Treatment resistant depression: what are the options?

BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k5354 (Published 18 December 2018) Cite this as: BMJ 2018;363:k5354

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Re: Treatment resistant depression: what are the options?

In a meta-analysis of 28 studies, 61% of patients treated with antidepressant pills still suffer from clinical depression after little more than a year.
"relapse–recurrence rates with pharmacotherapy of 61% (3.9% per month) over a mean of 68 weeks"
NICE’s definition of non responders greatly underestimates the real number of patients not helped by antidepressants.
Reference
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630051/

Competing interests: No competing interests

20 December 2018
Stavros Saripanidis
Consultant in Obstetrics and Gynaecology
Thessaloniki, Greece