Intended for healthcare professionals

Rapid response to:

Analysis Making Multisectoral Collaboration Work

Human papillomavirus immunisation of adolescent girls: improving coverage through multisectoral collaboration in Malaysia

BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4602 (Published 07 December 2018) Cite this as: BMJ 2018;363:k4602

Rapid Response:

Primum non nocere?

In the light of persistent and mounting concerns should we not rather be considering whether these programmes ought to continue?

Short bibliography:

Jørgensen L, Gøtzsche PC, Jefferson T.'The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias', BMJ Evid Based Med. 2018 Oct;23(5):165-168. doi: 10.1136/bmjebm-2018-111012. Epub 2018 Jul 27

Nigel Hawkes, 'Cochrane director’s expulsion results in four board members resigning', BMJ 2018; 362 doi: https://doi.org/10.1136/bmj.k3945 (Published 17 September 2018)

Lars Jørgensen, Peter Doshi, Peter Gøtzsche, Tom Jefferson, 'Challenges of independent assessment of potential harms of HPV vaccines', BMJ 2018; 362 doi: https://doi.org/10.1136/bmj.k3694 (Published 24 September 2018)

Riva C, Tinari S, Spinosa JP. 'Lessons learnt on transparency, scientific process and
publication ethics. The short story of a long journey to get into the public domain
unpublished data, methodological flaws and bias of the Cochrane HPV vaccines review.'
BMJ Evidence-Based Medicine Published Online First: 06 December 2018. doi:
10.1136/bmjebm-2018-111119

Emma Shardlow, Matthew Mold and Christopher Exley, 'Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action,', 7 November 2018, Allergy, Asthma & Clinical Immunology201814:80 https://doi.org/10.1186/s13223-018-0305-2

Gayle Delong, 'A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection', Journal of Toxicology and Environmental Health, https://www.tandfonline.com/doi/abs/10.1080/15287394.2018.1477640

Lee SH, 'Detection of human papillomavirus (HPV) L1 gene DNA possibly bound to particulate aluminum adjuvant in the HPV vaccine Gardasil, J Inorg Biochem. 2012 Dec;117:85-92. doi: 10.1016/j.jinorgbio.2012.08.015. Epub 2012 Aug 30.

Lee SH, 'Melting profiles may affect detection of residual HPV L1 gene DNA fragments in Gardasil®.', Curr Med Chem. 2014 Mar;21(7):932-40.

Lee SH, Vigliotti JS, Vigliotti V, Jones W, 'From Human Papillomavirus (HPV) Detection to Cervical Cancer Prevention in Clinical Practice', Cancers (Basel). 2014 Oct 2;6(4):2072-99. doi: 10.3390/cancers6042072.

Mary Holland, Kim Mack Rosenberg and Eileen Iorio, 'The HPV Vaccine On Trial: Seeking Justice for a Generation Betrayed' with an introduction by Luc Montagnier, Skyhorse, 2 October 2018

Competing interests: No competing interests

11 December 2018
John Stone
UK Editor
AgeofAutism.com
London N22