Intended for healthcare professionals

Rapid response to:

Analysis Making Multisectoral Collaboration Work

Human papillomavirus immunisation of adolescent girls: improving coverage through multisectoral collaboration in Malaysia

BMJ 2018; 363 doi: (Published 07 December 2018) Cite this as: BMJ 2018;363:k4602

Rapid Response:

Primum non nocere?

In the light of persistent and mounting concerns should we not rather be considering whether these programmes ought to continue?

Short bibliography:

Jørgensen L, Gøtzsche PC, Jefferson T.'The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias', BMJ Evid Based Med. 2018 Oct;23(5):165-168. doi: 10.1136/bmjebm-2018-111012. Epub 2018 Jul 27

Nigel Hawkes, 'Cochrane director’s expulsion results in four board members resigning', BMJ 2018; 362 doi: (Published 17 September 2018)

Lars Jørgensen, Peter Doshi, Peter Gøtzsche, Tom Jefferson, 'Challenges of independent assessment of potential harms of HPV vaccines', BMJ 2018; 362 doi: (Published 24 September 2018)

Riva C, Tinari S, Spinosa JP. 'Lessons learnt on transparency, scientific process and
publication ethics. The short story of a long journey to get into the public domain
unpublished data, methodological flaws and bias of the Cochrane HPV vaccines review.'
BMJ Evidence-Based Medicine Published Online First: 06 December 2018. doi:

Emma Shardlow, Matthew Mold and Christopher Exley, 'Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action,', 7 November 2018, Allergy, Asthma & Clinical Immunology201814:80

Gayle Delong, 'A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection', Journal of Toxicology and Environmental Health,

Lee SH, 'Detection of human papillomavirus (HPV) L1 gene DNA possibly bound to particulate aluminum adjuvant in the HPV vaccine Gardasil, J Inorg Biochem. 2012 Dec;117:85-92. doi: 10.1016/j.jinorgbio.2012.08.015. Epub 2012 Aug 30.

Lee SH, 'Melting profiles may affect detection of residual HPV L1 gene DNA fragments in Gardasil®.', Curr Med Chem. 2014 Mar;21(7):932-40.

Lee SH, Vigliotti JS, Vigliotti V, Jones W, 'From Human Papillomavirus (HPV) Detection to Cervical Cancer Prevention in Clinical Practice', Cancers (Basel). 2014 Oct 2;6(4):2072-99. doi: 10.3390/cancers6042072.

Mary Holland, Kim Mack Rosenberg and Eileen Iorio, 'The HPV Vaccine On Trial: Seeking Justice for a Generation Betrayed' with an introduction by Luc Montagnier, Skyhorse, 2 October 2018

Competing interests: No competing interests

11 December 2018
John Stone
UK Editor
London N22