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This review provides refreshing balance presenting the competing challenges of conventional RCTs and personalized medicine. It is a must read for young scientists, especially in the pivotal field of sepsis science, where a unified set of consensus thresholds is applied as a gold standard for the condition under test in RCTs despite the clear risk of marked HTE.
Sepsis science has tried three sets of unified consensus thresholds as standards for sepsis RCTs over the past 30 years. These RCTs have failed to render a single reproducibly positive result.
This excellent review should be read and studied by every young sepsis scientist.
I develop analytic software which processes subsets (phenotypes) of adverse condition.