Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic reviewBMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k3845 (Published 08 October 2018) Cite this as: BMJ 2018;363:k3845
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Matthews and colleagues found increases in venous thrombosis in breast cancer patients being treated with tamoxifen and increases in cardiovascular diseases in those treated with aromatase inhibitors.1 This is very interesting as venous changes including dilated venous sinusoids and venous thrombosis were more likely with combined oral contraceptives containing higher doses or balances of oestrogens. In contrast, peak doses or balances of progestogens caused most headaches, migraines, hypertension and thickened arteriolar walls.2-4 Endometrial and cranial blood vessel pictures are in my website lectures. http://www.harmfromhomones.co.uk
1 Matthews A, Stanway S, Parmer RE, Strongman H, et al. Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic review. BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k3845 (Published 08 October 2018) Cite this as: BMJ 2018;363:k3845
2 Grant ECG. Hormone balance of oral contraceptives. BJOG 1967;74:908-18.
3 Grant ECG. Venous effects of oral contraceptives. BMJ 1969;2:73-77.
4 Grant ECG. Relation between headaches from oral contraceptives and development of endometrial arterioles. BMJ 1968;3:402-05.
Competing interests: No competing interests
Re: Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic review
Here is yet more evidence of breast cancer screening harms. Alas, poor Cochrane! The overwhelming evidence that breast cancer screening harms greatly outweigh benefits seems to have resulted in cognitive dissonance. (Dissonance results when an individual must choose between attitudes and behaviours that are contradictory - but can be eliminated by reducing the importance of the conflicting beliefs (ignore the evidence), acquiring new beliefs that change the balance, (promote breast cancer screening – it's easier and less stressful) or removing the conflicting attitude or behaviour (oust Peter Gotzsche).
Competing interests: I campaign to raise awareness of evidence regarding harms versus benefit and advocate for women to be offered full information