Letters
Stopping of Viagra trial
Comprehensive literature search for animal studies may have saved STRIDER trial
BMJ 2018; 362 doi: https://doi.org/10.1136/bmj.k4007 (Published 25 September 2018) Cite this as: BMJ 2018;362:k4007
- Michael E Symonds, professor,
- Helen Budge, professor
- Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK
- michael.symonds{at}nottingham.ac.uk
The recent announcement that the STRIDER (sildenafil therapy in dismal prognosis early onset fetal growth restriction) trial intervention resulted in 11 infant deaths due to lung related problems raises many serious questions.12
The STRIDER summary cites only five animal studies that were considered supportive (four in small animal models).3 None examined pulmonary effects or postnatal consequences. Fetal development differs between small …
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