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It is a little-known but solidly documented fact that LDL partakes in the immune system by adhering to and inactivating all kinds of microorganisms (1-3). In accordance, low cholesterol is associated with an increased risk of all kinds of infectious disease (4). Therefore, the increase of sepsis deaths may be caused by the widespread use of statins. A case-control study comparing the use of statins among patients with sepsis and healthy controls of the same age and sex may be able to verify this hypothesis.
1. Ravnskov U. High cholesterol may protect against infections and atherosclerosis. QJM 2003;96:927-34.
2. Ravnskov U, McCully KS. Vulnerable plaque formation from obstruction of vasa vasorum by homocysteinylated and oxidized lipoprotein aggregates complexed with microbial remnants and LDL autoantibodies. Ann Clin Lab Sci 2009;39:3-16.
3. Ravnskov U, McCully KS. Infections may be causal in the pathogenesis of atherosclerosis. Am J Med Sci 2012;344:391-4.
4. Iribarren C, Jacobs DR Jr, Sidney S, et al. Cohort study of serum total cholesterol and in-hospital incidence of infectious diseases. Epidemiol Infect 1998;121:335–47