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Letters Valproate and pregnancy

Prescribing in pregnancy shows the weaknesses in pharmacovigilance

BMJ 2018; 361 doi: https://doi.org/10.1136/bmj.k2334 (Published 29 May 2018) Cite this as: BMJ 2018;361:k2334
  1. Alain Braillon, senior consultant1,
  2. Susan Bewley, professor of complex obstetrics2
  1. 1University Hospital, 80000 Amiens, France
  2. 2Women’s Health Academic Centre, King’s College London, London, UK
  1. braillon.alain{at}gmail.com

Even the most recent of several commendable articles in The BMJ on epilepsy and valproate during pregnancy missed that regulatory agencies should have acted earlier.1

The first report of malformations due to valproate was in 1982.2 Despite many meetings and reports, no action was taken until 2015, when a legal case went public, thanks to a mother whose two children, one after the other, were damaged. She also …

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