Re: HPV vaccines are effective and safe and work best in young women, review finds
I have asked the following question of the Cochrane review, I await any reply.
May I ask the exact nature of the placebos used for the control groups in each of the safety / efficacy trials covered by this review? It is my understanding that on many if not all occasions the placebo was entirely inappropriate. Where Cervarix is concerned i have brought up this flaw in the scientific method in a letter in Lancet Infectious Disease. Where Gardasil is concerned the reluctance of Merck to share their proprietary adjuvant has made closer investigations impossible. As I wrote in Vaccine many years ago now, aluminium adjuvants are not appropriate placebos in vaccine safety trials.
Competing interests: No competing interests