Intended for healthcare professionals


Donald Eccleston

BMJ 2018; 361 doi: (Published 18 May 2018) Cite this as: BMJ 2018;361:k2054
  1. Ian McKeith

Donald Eccleston (“Don”) was one of the first to elaborate a hypothesis of depression that argued for a role of monoamines, particularly 5-hydroxytryptamine (5-HT), in the regulation of mood, and who translated his experimental observations into treatment for patients with refractory depressive disorders. He devised the “Newcastle cocktail” (phenelzine, L-tryptophan, and lithium)—a pharmacological strategy that offered a window of …

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