Intended for healthcare professionals

Clinical Review State of the Art Review

Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications

BMJ 2018; 361 doi: https://doi.org/10.1136/bmj.k1036 (Published 23 April 2018) Cite this as: BMJ 2018;361:k1036

Re: Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications

We thank Crilly and colleagues for their interest in our State of the Art review and the literature search strategies in the other State of the Art reviews. The State of the Art reviews provide a summary of the literature condensed into an up-to-date review of the topic for clinicians and researchers. The commission is not for a systematic literature review of the topic, and the search strategy is not described as such. There are strengths and tradeoffs for different literature search approaches including reproducibility, exhaustiveness, resources required, and breadth of topic that can be covered, among others. Conducting a systematic literature review of our topic would have necessitated narrowing the scope of the review, which we believe would not have provided readers with an adequate understanding of the breadth of mechanisms and implications of cardiovascular disease in rheumatoid arthritis.

Bryant R. England, MD
Assistant Professor
Division of Rheumatology & Immunology
VA Nebraska-Western Iowa Health Care System
University of Nebraska Medical Center
Omaha, NE, U.S.A

Ted R. Mikuls, MD, MSPH
Umbach Professor of Rheumatology
Division of Rheumatology & Immunology
VA Nebraska-Western Iowa Health Care System
University of Nebraska Medical Center
Omaha, NE, U.S.A

Competing interests: No competing interests

10 July 2018
Bryant R England
Rheumatologist
Ted R Mikuls, MD, MSPH
VA Nebraska-Western IA Health Care System, University of Nebraska Medical Center
986270 Nebraska Med Center, Omaha, NE USA