Intended for healthcare professionals

Letters Improving animal research

Improving animal research: PREPARE before you ARRIVE

BMJ 2018; 360 doi: (Published 22 February 2018) Cite this as: BMJ 2018;360:k760
  1. Adrian J Smith, secretary1,
  2. R Eddie Clutton, director2,
  3. Elliot Lilley, senior scientific officer3,
  4. Kristine E Aa Hansen, assistant professor4,
  5. Trond Brattelid, research adviser5
  1. 1Norecopa, c/o Norwegian Veterinary Institute, PO Box 750, Sentrum, 0106 Oslo, Norway
  2. 2Wellcome Trust Critical Care Laboratory for Large Animals, Roslin Institute, Easter Bush EH25 9RG, UK
  3. 3Research Animals Department, Science Group, RSPCA, Wilberforce Way, Southwater, Horsham RH13 9RS, UK
  4. 4Section of Experimental Biomedicine, Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, PO Box 8146 Dep, 0033 Oslo, Norway
  5. 5Division for Research Management and External Funding, Western Norway University of Applied Sciences, 5020 Bergen, Norway
  1. adrian.smith{at}

Despite widespread journal endorsement of reporting guidelines, the poor reproducibility of preclinical research is increasingly under debate.1234 Ritskes-Hoitinga and Wever cite preregistration, systematic reviews, and better reporting as major tools for raising standards of animal research.5

An elephant in the room has been ignored for too long—better reporting does not improve the quality of an experiment that has already been …

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