Diet, genes, and obesityBMJ 2018; 360 doi: https://doi.org/10.1136/bmj.k7 (Published 10 January 2018) Cite this as: BMJ 2018;360:k7
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Obesity is one of the non-communicable diseases. The various hypotheses on the prevalence and management of obesity include improper dietary pattern, stress, lack of physical activity, genetic predisposition, atomic model and molecular model, while one of the newer hypotheses concerns Gut microbiota. The Hypothesis of Gut microbiota makes the interrelation between the Gut microbiota and impairment of lipid metabolism.
In the management of communicable disorders, Antibiotics are always stood first, which may affect the gut microbiome, playing an important role in the impairment of lipid metabolism and resulting in Obesity (1). These changes are mainly due to the mutagenic changes in the Mitochondria. This indicates that Mitochondrial dysfunction increases the risk of the prevalence of Obesity (2). In the present day, improper and extensive use of antibiotics causes mutagenic changes in mitochondrial DNA, leading to the manifestation of obesity (3).
There are various kinds of obesity management from diet to surgery. The interprofessional management of obesity using Behavioral lifestyle modification, pharmacotherapy, proper education, proper usage of social media is a new approach (4). This can be achieved by suitable planning, operation, and analysis of SWOT (strengths, weaknesses, opportunities, and threats) components of the interprofessional system.
1. Tremaroli V, Backhed F: Functional interactions between the gut microbiota and host metabolism. Nature 2012; 489:242–249.
2. Borengasser SJ, Faske J, Kang P, Blackburn ML, Badger TM, Shankar K: In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Physiol Genomics 2014; 46: 841–850.
3. Andrade MJ, Jayaprakash C, Bhat S, Evangelatos N, Brand A, Satyamoorthy K. Antibiotics-Induced Obesity: A Mitochondrial Perspective. Public health genomics. 2017 Dec 15.
4. Alnaami MY. Prevention and control of obesity: An inter professional system approach. Saudi J Obesity 2016;4:59-67.
Competing interests: No competing interests