Research News

A third of clinical trials publishing interim findings fail to report final results, review finds

BMJ 2018; 360 doi: https://doi.org/10.1136/bmj.k317 (Published 23 January 2018) Cite this as: BMJ 2018;360:k317
  1. Susan Mayor
  1. London

More than one third of clinical trials publishing interim findings fail to report final results and one in five change their conclusions in final publications, a review of randomised trials has found.1

Researchers searched PubMed for all randomised trials published between 1 January 2006 and 31 December 2015 reporting interim results, excluding pilot studies, protocols, and cancer trials reporting final primary results but interim secondary outcomes. They then searched for final publications and compared the findings, or contacted the authors if no final publication could be found.

Results, reported in JAMA, showed that final results were published for only 61% of …

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