Intended for healthcare professionals

Editor's Choice

We need better animal research, better reported

BMJ 2018; 360 doi: https://doi.org/10.1136/bmj.k124 (Published 11 January 2018) Cite this as: BMJ 2018;360:k124
  1. Fiona Godlee, editor in chief
  1. The BMJ
  1. fgodlee{at}bmj.com

New drug development is underpinned by animal research, but is the animal evidence base fit for purpose? A collection of articles published in The BMJ this week suggest not. They conclude that the preclinical foundations of clinical research are shaky and in urgent need of reform.

The articles focus on one example: the testing of a new vaccine, MVA85A, designed as a booster to BCG vaccine to improve the prevention of tuberculosis. Vaccine researchers were shocked when a large trial in South African infants failed …

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