Re: Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis
A basic tenet of Medelian randomization, is that genetic polymorphisims are distributed randomly in the polpulation (panmixia).
This assumption may not hold, for genes associated with educational attainment, as people generally choose mates with similar social-economic backgrounds.
Has the assumption of random genetic distribution been assessed?
Competing interests: No competing interests