Intended for healthcare professionals

CCBYNC Open access
Research

Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis

BMJ 2017; 359 doi: https://doi.org/10.1136/bmj.j5375 (Published 07 December 2017) Cite this as: BMJ 2017;359:j5375

Re: Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis

A basic tenet of Medelian randomization, is that genetic polymorphisims are distributed randomly in the polpulation (panmixia).
This assumption may not hold, for genes associated with educational attainment, as people generally choose mates with similar social-economic backgrounds.
Has the assumption of random genetic distribution been assessed?

Competing interests: No competing interests

19 December 2017
Tzippy Shochat
Statistical Consultant
Rabin Medical Center, Israel
Modiin. Israel