Intended for healthcare professionals

CCBYNC Open access
Research

Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis

BMJ 2017; 359 doi: https://doi.org/10.1136/bmj.j5375 (Published 07 December 2017) Cite this as: BMJ 2017;359:j5375

Re: Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis - Not actually about Alzheimer Disease

This paper isn't actually about Alzheimer disease (AD). AD is a pathologic diagnosis and this analysis is based largely on clinical classifications. The most common cause of what is usually called AD in clinical practice is mixed dementia with a combination of neurodegenerative, including AD, pathologies and vascular brain injury. It is very clear that education has a major impact on general health and cardiovascular health and is likely a major contributor to the decline in age-specific dementia incidence now documented in several developed nations.

Competing interests: No competing interests

15 December 2017
Roger L. Albin
Professor of Neurology
University of Michigan
5023 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200