Re: Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis - Not actually about Alzheimer Disease
This paper isn't actually about Alzheimer disease (AD). AD is a pathologic diagnosis and this analysis is based largely on clinical classifications. The most common cause of what is usually called AD in clinical practice is mixed dementia with a combination of neurodegenerative, including AD, pathologies and vascular brain injury. It is very clear that education has a major impact on general health and cardiovascular health and is likely a major contributor to the decline in age-specific dementia incidence now documented in several developed nations.
Competing interests: No competing interests