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Rapid response to:


Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study

BMJ 2017; 359 doi: (Published 20 November 2017) Cite this as: BMJ 2017;359:j5019

Rapid Response:

Very important albeit overlooked variables: age, central obesity, and acanthosis nigricans

The article is highly relevant in day-to-day clinical practice. The incidence of Type 2 DM is highly influenced by other important albeit overlooked variables: age (increase with increasing age, increase with increase in central obesity, particularly intra-abdominal fat, and increase with presence of acanthosis nigricans, the cutaneous manifestation of insulin resistance). I am sure c-statistic could have been much improved, if these easily and clinically measured variables could have been included in the analysis.

In future, analysis of these easily and clinically measured variables, could be considered with advantage.

Competing interests: No competing interests

18 December 2017
Rajeev Gupta
Consultant cardiologist
Mediclinic Al Jowhara Hospital, Al Ain, UAE
Mediclinic Al Jowhara Hospital, Al Ain, UAE