Intended for healthcare professionals

Letters Difficult to treat severe asthma

Improving quality of life relies on valid outcome measures as well as drugs

BMJ 2017; 359 doi: (Published 12 October 2017) Cite this as: BMJ 2017;359:j4623
  1. Rupert C Jones, senior clinical research fellow1,
  2. Matthew Masoli, consultant physician2,
  3. Joseph W Lanario, associate research fellow1,
  4. Michael E Hyland, professor of health psychology3
  1. 1Community and Primary Care, Peninsula School of Medicine and Dentistry, University of Plymouth, Plymouth PL4 8BX, UK
  2. 2Plymouth Hospital’s NHS Trust, Plymouth, UK
  3. 3School of Psychology, University of Plymouth of Plymouth, Plymouth, UK
  1. rupert.jones{at}

The review from the Drug and Therapeutics Bulletin on managing difficult to treat asthma1 states that studies of novel biological agents have shown marked improvements in the frequency of exacerbations and healthcare consumption and reductions in oral steroid dosage but that limited evidence shows benefits in quality of life. Failure to detect quality of life …

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