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No overall increase in all cause mortality with HRT, study finds

BMJ 2017; 358 doi: (Published 12 September 2017) Cite this as: BMJ 2017;358:j4230
  1. Jacqui Wise
  1. London

The results of 18 years of follow-up should provide reassurance that there is no long term increase in all cause mortality or mortality from specific causes, such as cardiovascular disease or cancer, among women who received hormone replacement therapy (HRT) for five to seven years.1

The results of the study, published in JAMA, show that it is appropriate to offer HRT to women experiencing menopausal symptoms such as hot flushes and night sweats. However, the study found no long term reductions in all cause mortality among women who used HRT, so the results do not support using it for the prevention of cardiovascular or other chronic disease.

The effect of HRT on cancer mortality, especially breast cancer mortality, has been a subject of debate and has generated concern among women and a reluctance to prescribe among some GPs. The latest findings support the current NICE guidance published in 2015 …

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