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Food-drug or herb-drug or drug-drug interactions are common in those who have dietary intolerance or allergies. This may be Pharmacokinetic or pharmacodynamic in nature. It is observed that the prevalence of concomitant administration excipients in conventional medications will increase the probability of Dietary intolerance or Allergies. To date, there is no standard system for evaluating the excipients and their role in drug interaction in medicines. So this is the right time to develop patient-specific and drug-specific variables that can affect Pharmacokinetic or pharmacodynamics of any dosage modalities especially oral dosage forms.
Absorption of all oral dosage modalities is under the influence of range of factors such as bioavailability, passive transporters, active transporters and drug absorption. Drug transporters have a role in drug development like distribution of drug distribution and facilitation of the transport across the cell (1), etc. The discipline of Drug transporters deals with transport biology and has grown remarkably over the last decade. This specialized field plays a significant role in disease manifestation and its management. Drug transporters help in recognizing those factors that may modify the time and rate of drug absorption. There are many types of Drug transporters now existing in practice. For instance, Membrane transporters directly affecting drug absorption (2). P-glycoprotein is a membrane transporter (drug transporter) that plays a vital role in drug absorption and bioavailability. Medicine excipients in dosage modalities are a special class of P-glycoprotein inhibitors (3). It is observed that P-glycoprotein inhibiting excipients reported are non-absorbable, and they will inhibit P-glycoprotein only in the gastrointestinal tract. So this is the right time to focus more on drug transporters to overcome drug intolerance and allergies.
References:
1. Hediger M.A., et al. The ABCs of membrane transporters in health and disease (SLC series): Introduction.Molecular Aspects of Medicine 2013; 34: 95–107
2. Martinez, M.N., Amidon, G.L., A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals. The Journal of Clinical Pharmacology, 2002; 42: 620–643.
3.Varma M, V, Ashokraj Y, Dey C.S, Panchagnula.R., P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement Pharmacol. Res.2003; 48: 347-359.
Competing interests:
No competing interests
30 November 2017
Kamath Madhusudhana
Associate Professor
Division of Ayurveda ,Center for Integrative Medicine and Research ( CIMR ) Manipal University ,Manipal.
Role of Drug transporters in Designing Medicine.
Food-drug or herb-drug or drug-drug interactions are common in those who have dietary intolerance or allergies. This may be Pharmacokinetic or pharmacodynamic in nature. It is observed that the prevalence of concomitant administration excipients in conventional medications will increase the probability of Dietary intolerance or Allergies. To date, there is no standard system for evaluating the excipients and their role in drug interaction in medicines. So this is the right time to develop patient-specific and drug-specific variables that can affect Pharmacokinetic or pharmacodynamics of any dosage modalities especially oral dosage forms.
Absorption of all oral dosage modalities is under the influence of range of factors such as bioavailability, passive transporters, active transporters and drug absorption. Drug transporters have a role in drug development like distribution of drug distribution and facilitation of the transport across the cell (1), etc. The discipline of Drug transporters deals with transport biology and has grown remarkably over the last decade. This specialized field plays a significant role in disease manifestation and its management. Drug transporters help in recognizing those factors that may modify the time and rate of drug absorption. There are many types of Drug transporters now existing in practice. For instance, Membrane transporters directly affecting drug absorption (2). P-glycoprotein is a membrane transporter (drug transporter) that plays a vital role in drug absorption and bioavailability. Medicine excipients in dosage modalities are a special class of P-glycoprotein inhibitors (3). It is observed that P-glycoprotein inhibiting excipients reported are non-absorbable, and they will inhibit P-glycoprotein only in the gastrointestinal tract. So this is the right time to focus more on drug transporters to overcome drug intolerance and allergies.
References:
1. Hediger M.A., et al. The ABCs of membrane transporters in health and disease (SLC series): Introduction.Molecular Aspects of Medicine 2013; 34: 95–107
2. Martinez, M.N., Amidon, G.L., A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals. The Journal of Clinical Pharmacology, 2002; 42: 620–643.
3.Varma M, V, Ashokraj Y, Dey C.S, Panchagnula.R., P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement Pharmacol. Res.2003; 48: 347-359.
Competing interests: No competing interests