Limited evidence, faulty reasoning, and potential for a global opioid crisis
BMJ 2017; 358 doi: https://doi.org/10.1136/bmj.j3115 (Published 05 July 2017) Cite this as: BMJ 2017;358:j3115
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This editorial is of public health relevance since the use of routine prescription opioid for chronic pain can lead to addiction. Studies have shown that a minority of individuals prescribed opioids may develop abuse or addiction (1). The chances of substance use disorders are increased with long-term use of prescription opioids (2,3). Hence, there should be cautious and limited prescription of opioids in health care settings. Private practitioners should also withheld the prescription of opioids, and there should be mechanisms to monitor the use of opioids by both government agencies and pharmacists or chemist shops. The relevant law on narcotics use such as the National Drug and Psychotropic Substances Act in India should be implemented stringently wherever any such law exists. Otherwise indiscriminate use will lead to more substance abuse problems and limited opioid supply when needed. There should be education campaigns among the medical professionals through organisations such as the Indian Medical Association and others. Sensitisation of doctors is a must whether practising in public or private health care set ups.
References
1. Fishbain DA, Cole B, Lewis J, Rosomoff HL, Rosomoff RS. What percentage of chronic non malignant pain patients exposed to chronic opioid analgesic therapy develop abuse/addiction and/or aberrant drug-related behaviors? A structured evidence-based review. Pain Med. 2008;9:444–59.
2. Breckenridge J, Clark JD. Patient characteristics associated with opioid versus non steroidal anti-inflammatory drug management of chronic low back pain. J Pain. 2003; 4:344–50.
3. Hermos JA, Young MM, Gagnon DR, Fiore LD. Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients. Arch Intern Med. 2004; 164:2361–6.
Competing interests: No competing interests
This warning is timely, but the emphasis on the commercial aspect of opioid prescribing might be falsely reassuring for prescribers in the NHS. Drug related deaths in middle age are increasing here too. As there are clear cohort effects in this phenomenon the official thinking seems to be that drug related deaths mostly involve ageing addicts who took up the habit decades ago. However the UK government reports a doubling of opioid prescriptions in the last ten years and the likelihood of addiction arising from legitimately prescribed analgesia seems high. A pertinent question might be around the underlying vulnerability in this cohort which makes them prone to addiction.
Competing interests: No competing interests
Re: Limited evidence, faulty reasoning, and potential for a global opioid crisis
As this article notes, the use of opiates at the end of life can be humane and appropriate. However, if we are to avoid them getting into the wrong hands when they are no longer needed, and feeding the current opioid addiction crisis, extra safeguards are needed.
From my personal experience, opiates and other dangerous medicines may be left at home after a death, with instructions to return them to a pharmacy. If the bereaved are too distressed to do this, the medicines may just be left in the home, waiting to be abused or discovered by small grandchildren.
Others have reported this problem, would it not be possible for a community pharmacist to join the end of life team and take control of the situation?
1. 1) Maxine de la Cruz, Akhila Reddy, Vishidha Balankari, et al;The Impact of an Educational Program on Patient Practices for Safe Use, Storage, and Disposal of Opioids at a Comprehensive Cancer Center:
The Oncologist July 2017 , 22 (7)
10.1634/theoncologist.2016-0266:
2) Frequency of unsafe storage, use, and disposal practices of opioids among cancer patients presenting to the emergency department
Julio Silvestre ,Akhila Reddy ,Maxine de la Cruz ,et al ...
Palliative and supportive care 13th April 2016
https://doi.org/10.1017/S1478951516000158
Competing interests: No competing interests