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Family history is strong risk factor in BRCA1 and BRCA2 carriers, study finds

BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j3020 (Published 22 June 2017) Cite this as: BMJ 2017;357:j3020
  1. Jacqui Wise
  1. London

The risk of developing breast cancer in women who carry BRCA1 or BRCA2 mutations increases with the number of relatives who have a breast cancer diagnosis, a large prospective cohort study published in JAMA has found.1

The study also found that cancer risk varied by mutation position within the BRCA1 or BRCA2 mutations. The findings suggest that individualised counselling for women with either mutation should incorporate family history profiles and the mutation site, the researchers said. …

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