Intended for healthcare professionals

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Research

Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis

BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.j760 (Published 14 March 2017) Cite this as: BMJ 2017;356:j760

Rapid Response:

RE: Drug Interactions between benzodiazepines and opioids & back to basics of Pharmacology.

This is good to read a research article on "Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis" [1].
The harmful drug interaction of benzodiazepines and opioids is depressed respiration and increased sedation. This is related to additive actions of both the drugs, benzodiazepines slow down the central nervous system.
FDA is requiring boxed warnings on all opioid analgesic and benzodiazepine and also warn patients of the potential dangers of combined use of opioids and benzodiazepines [2,3].
Health care provider should not forget the "Pharmacology principles" in therapy, that play the role in patients care.

Regards,
Dr Rajiv Kumar
Faculty, Dept. of Pharmacology,
Government Medical College & Hospital Chandigarh-160030, India.
References:
1. BMJ 2017;356:j760
2. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm518697.htm
3. https://www.fda.gov/Drugs/DrugSafety/ucm518473.htm

Competing interests: No competing interests

15 March 2017
Dr.Rajiv Kumar
Faculty
Dept. of Pharmacology, Government Medical College & Hospital Chandigarh 160030. India.
DRrajiv.08@gmail.com