Intended for healthcare professionals

Letters Interventions in UK fertility centres

Continuing to deliver: the evidence base for pre-implantation genetic screening

BMJ 2017; 356 doi: (Published 14 February 2017) Cite this as: BMJ 2017;356:j752
  1. Darren K Griffin, professor of genetics1,
  2. Simon Fishel, president and head of research and development2,
  3. Tony Gordon, managing director and laboratory director3,
  4. Yuval Yaron, director4,
  5. Jamie Grifo, program director5,
  6. Ariel Hourvitz, director6,
  7. Svetlana Rechitsky, laboratory director7,
  8. Janine Elson, consultant gynaecologist2,
  9. Joshua Blazek, senior scientist3,
  10. Francesco Fiorentino, founder and chief executive officer8,
  11. Nathan Treff, director of molecular biology9,
  12. Santiago Munne, founder and director10,
  13. Milton Leong, adjunct professor11,
  14. Andreas Schmutzler, co-director12,
  15. Attila Vereczkey, medical director13,
  16. Tarek Ghobara, consultant obstetrician14,
  17. László Nánássy, laboratory director13,
  18. Michael Large, laboratory director15,
  19. Samir Hamamah, medical head16,
  20. Robert Anderson, founder17,
  21. Luca Gianaroli, director18,
  22. Dagan Wells, director19
  1. 1School of Biosciences, University of Kent, Canterbury, UK
  2. 2CARE Fertility Group UK, Nottingham, UK
  3. 3Genesis Genetics US, Plymouth, MI, USA
  4. 4Unit for Prenatal Genetic Diagnosis, Genetic Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  5. 5New York University (NYU) Langone Fertility Center, New York, NY, USA
  6. 6Reproduction Laboratory, Sackler School of Medicine, Tel Aviv, Israel
  7. 7Reproductive Genetic Innovations, Northbrook, IL, USA
  8. 8Genoma Group, Molecular Genetics Laboratories, Rome, Italy
  9. 9Reproductive Medicine Associates of New Jersey, USA
  10. 10Reprogenetics, Livingston, NJ, USA
  11. 11McGill University, Montreal, Canada
  12. 12gyn-medicum IVF Center, Goettingen, Germany
  13. 13Versys Clinics Human Reproduction Institute, Budapest, Hungary
  14. 14University Hospitals Coventry and Warwickshire, Coventry, UK
  15. 15Cooper Genomics, Houston, TX, USA
  16. 16ART/PGD department, INSERM, Montpellier, France
  17. 17Southern California Center for Reproductive Medicine, Newport Beach, CA, USA
  18. 18SISMeR Reproductive Medicine Unit, Bologna, Italy
  19. 19Preimplantation Genetic Diagnosis Laboratory, University of Oxford, NIHR Biomedical Research Centre, Oxford, UK
  1. d.k.griffin{at}

We respond to the comments made in the BBC commissioned article by Heneghan and colleagues and the Panorama programme by Deborah Cohen about pre-implantation genetic screening (PGS), which was among the three “add on” treatments highlighted in the programme and the 41 listed in the article.12 Currently an extensive evidence base supports the efficacy of PGS: more than 20 retrospective studies and four randomised controlled trials suggest that, if performed to a high standard, PGS can, and does, improve IVF success for some patient groups.34567 We accept, however, that all studies are open to criticism and thus support further investigations, randomised and retrospective. However, the programme, …

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