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Off-label indications for antidepressants in primary care: descriptive study of prescriptions from an indication based electronic prescribing system

BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.j603 (Published 21 February 2017) Cite this as: BMJ 2017;356:j603

Antidepressants carry mortality risks

Recent evidence reveals that administered antidepressants increase suicide risks by 2-5 times. [1][2][3][4][5][6]
A recent meta-analysis, level I evidence, clearly demonstrated that SSRIs double the risk of suicide and violence in adults. [3]
Furthermore, antidepressants increase all cause mortality by 33%! [7][8]
References
[1] http://journals.sagepub.com/doi/pdf/10.1177/0141076816666805
[2] http://www.bmj.com/content/348/bmj.g3510
[3] http://www.bmj.com/content/352/bmj.i65
[4] http://nordic.cochrane.org/sites/nordic.cochrane.org/files/public/upload...
[5] http://www.bmj.com/content/355/bmj.i6103
[6] http://www.bmj.com/content/358/bmj.j3697/rr-4
[7] http://dailynews.mcmaster.ca/article/antidepressants-associated-with-sig...
[8] https://www.ncbi.nlm.nih.gov/pubmed/28903117

Competing interests: No competing interests

08 November 2017
Stavros Saripanidis
Consultant in Obstetrics and Gynaecology
Thessaloniki, Hellas