Letters
Sex based differences in trials
Sex can affect participation, engagement, and adherence in trials
BMJ 2016; 355 doi: https://doi.org/10.1136/bmj.i6754 (Published 30 December 2016) Cite this as: BMJ 2016;355:i6754
- Alison Avenell, clinical chair in health services research1,
- Clare Robertson, research fellow1,
- Fiona Stewart, research fellow1,
- Dwayne Boyers, research fellow2,
- Flora Douglas, lecturer in public health3,
- Daryll Archibald, research fellow4,
- Edwin van Teijlingen, professor of reproductive health research5,
- Pat Hoddinott, chair in primary care6,
- Charles Boachie, statistician7
- 1Health Services Research Unit, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
- 2Health Services Research Unit and Health Economics Research Unit, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
- 3Rowett Institute of Nutrition and Health, School of Medicine, Medical Science and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
- 4Scottish Collaboration for Public Health Research and Policy (SCPHRP), Centre for Population Health Sciences (CPHS), University of Edinburgh, Edinburgh EH8 9DX, UK
- 5Centre for Midwifery, Maternal and Perinatal Health, Faculty of Health and Social Sciences, Bournemouth House, Bournemouth University, Bournemouth BU1 3LH, UK
- 6NMAHP Research Unit, Unit 13, Scion House, Stirling University Innovation Park, Stirling FK9 4NF, UK
- 7Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 9QQ, UK
- a.avenell{at}abdn.ac.uk
We enjoyed Wallach and colleagues’ analysis of sex based subgroup differences in randomised controlled trials in the Cochrane Library.1 The authors found little evidence for clinically relevant sex-treatment interactions for outcomes.
Not apparent in their analysis are the social, psychological, and contextual factors that can influence men’s and women’s …
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