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Thiazide diuretics seem to protect against fracture

BMJ 2016; 355 doi: (Published 22 November 2016) Cite this as: BMJ 2016;355:i6263
  1. Jacqui Wise
  1. Kent

Thiazide diuretics are associated with a reduced risk of hip and pelvic fractures compared with treatment with other antihypertensive drugs, according to a randomised trial reported in JAMA Internal Medicine.1

The secondary analysis of the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) found a 21% lower risk of hip and pelvic fractures associated with chlorthalidone compared with either …

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