Interpreting cancer gene reports . . . and other storiesBMJ 2016; 355 doi: https://doi.org/10.1136/bmj.i5408 (Published 12 October 2016) Cite this as: BMJ 2016;355:i5408
Cancer gene reports depend on the laboratory
Gene sequencing technology has outrun our ability to interpret its findings consistently. The ClinVar database was set up to encourage clinical laboratories to submit genetic variants identified by massive parallel sequencing and to share their interpretation. In the PROMPT study of cancer susceptibility genes, 518 participants (603 genetic variants) had a result interpreted by more than one laboratory, including at least one submitted to ClinVar (J Clin Oncol doi:10.1200/JCO.2016.68.4316). The interpretation differed among reporting laboratories for 155 (26%).
Diabetes drugs in the USA
The use of glucose lowering drugs changed markedly in the United States between 2006 and 2013, according to claims data from 1.66 million privately insured and Medicare Advantage patients (Diabetes Care doi:10.2337/dc16-0985). Use of thiazolidinediones …