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Letters Congenital Zika syndrome

Congenital Zika syndrome: time to move from case series to case-control studies and data sharing

BMJ 2016; 354 doi: (Published 14 September 2016) Cite this as: BMJ 2016;354:i4850
  1. Patrick Gérardin, epidemiologist1,
  2. Hanitra Randrianaivo, foetopathologist2,
  3. Bruno Schaub, gynaecologist-obstetrician3,
  4. Raymond Césaire, virologist4,
  5. Bérénice Doray, geneticist5,
  6. A Désirée LaBeaud, infectious diseases specialist6
  1. 1INSERM CIC 1410, CHU Réunion, BP 350, 97448 Saint Pierre Cedex, Réunion
  2. 2JRC/EUROCAT affiliated Registry of Congenital Birth Defects, Saint Pierre, Réunion
  3. 3Centre Pluridisciplinaire de Diagnostic Prénatal, CHU de Martinique, Fort de France, French West Indies
  4. 4Virology Unit, CHU de Martinique, Fort de France, French West Indies
  5. 5Department of Genetics, CHU Réunion, Saint Denis, Réunion
  6. 6Department of Pediatrics, Stanford School of Medicine, Palo Alto, CA, USA
  1. patrick.gerardin{at}

We welcome the paper reporting seven cases of congenital Zika syndrome (CZS) with arthrogryposis.1 Mounting evidence that Zika virus infection in early gestation causes brain damage shows that Zika associated arthrogryposis may be neurogenic. In agreement, the mechanisms underlying the CZS phenotype would be a tropism of the virus to neuronal cells,2 3 or vascular disorders, as in the …

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