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Variability in LDL cholesterol is linked to poorer cognitive performance in older people

BMJ 2016; 354 doi: (Published 20 July 2016) Cite this as: BMJ 2016;354:i4040
  1. Susan Mayor
  1. London

Greater variability in low density lipoprotein (LDL) cholesterol is associated with poorer cognitive performance in older people, a large international study has shown.1

Researchers assessed the association between variability in LDL cholesterol and tests of cognitive function in 4428 people (aged 70 to 82) with pre-existing vascular disease or at increased risk of vascular disease who were taking part in a prospective randomised trial of pravastatin. They also looked at the impact of LDL cholesterol variability on levels of white matter in the brain …

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