Assessment and management of cirrhosis in people older than 16 years: summary of NICE guidanceBMJ 2016; 354 doi: https://doi.org/10.1136/bmj.i2850 (Published 06 July 2016) Cite this as: BMJ 2016;354:i2850
- P Harrison, consultant hepatologist1,
- B J Hogan, specialist registrar (ST7) in intensive care medicine and hepatology2,
- L Floros, health economist3,
- E Davies, senior research fellow3
- on behalf of the Guideline Development Group
- 1Kings College Hospital, London SE5 9RS, UK
- 2Guys’s & St Thomas’ Hospitals NHS Foundation Trust, London, UK
- 3National Guideline Centre, Royal College of Physicians, London NW1 4LE, UK
- Correspondence to: E Davies
What you need to know
Offer testing for cirrhosis to those at higher risk, including those with:
Alcohol related liver disease
Non-alcoholic fatty liver disease and advanced liver fibrosis
Alcohol intake >50 units per week in men and >35 units in women for several months
Non-invasive transient elastography or acoustic radiation force impulse imaging is the first line investigation
Refer those with cirrhosis to a hepatologist
Clinical identification of cirrhosis remains imperfect, especially in people with compensated disease who are often asymptomatic. There is considerable variation in practice across England and Wales with regard to who is tested for cirrhosis and the diagnostic tests used.1 We provide guidance to aid diagnosis of cirrhosis, referral to specialist care for those at high risk of liver decompensation before they experience a defining event, and management of people with cirrhosis, including surveillance for and treatment of complications.
Liver disease is the third most common cause of premature death in the UK. In England and Wales 60 000 people (1 in 1000) have cirrhosis, and mortality rates have increased by 400% since the 1970s.2 Liver biopsy was historically the standard test for the diagnosis of cirrhosis for all causes of liver disease. However, liver biopsy is associated with complications, such as pain and bleeding; it is an expensive test and is less acceptable to patients because of the morbidity associated with its use.3 New diagnostic technologies such as transient elastography and acoustic radiation force impulse imaging can diagnose cirrhosis with >90% sensitivity, and mean that it is now practical and acceptable to offer testing to a greater number of people.
The Guideline Development Group (GDG) believe that
Earlier diagnosis of cirrhosis may offer more opportunity for treatments, limiting disease progression and avoiding complications.
These recommendations—particularly early diagnosis, effective surveillance, and early access to specialist care—will …